Preclinical studies of N3-O-toluyl-fluorouracil-loaded lipid-based nanosuspensions in H22-bearing mice
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چکیده
منابع مشابه
Preclinical studies of N3-O-toluyl-fluorouracil-loaded lipid-based nanosuspensions in H22-bearing mice
PURPOSE N3-O-toluyl-fluorouracil (TFU) is a potential antitumor prodrug of 5-fluorouracil (5-FU), but its poor solubility has limited its use in clinic. This study aimed to improve the bioavailability of TFU by preparing TFU-loaded lipid-based nanosuspensions (TFU-LNS) and perform a preclinical evaluation. METHODS TFU-LNS were prepared through high-pressure homogenization and were lyophilized...
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ژورنال
عنوان ژورنال: International Journal of Nanomedicine
سال: 2014
ISSN: 1178-2013
DOI: 10.2147/ijn.s59338